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Population-based studies indicate a significant association of migraine with aura and atrial fibrillation. Ablation therapy for atrial fibrillation in patients with migraine might reduce migraine attacks, but transient post-ablation new-onset migraine-like headaches in persons without a history of migraine have also been reported. Studies investigating patients with ischaemic stroke and migraine are methodologically insufficient and provide contradictory results. An even larger population-based study in Denmark confirmed this association (odds ratio 1.25, 95% confidence interval 1.16–1.36). The not-so-good news: People who suffer migraines (even without aura) are more likely to eventually have some type of heart or vascular problem. The population-based Atherosclerosis Risk in Communities study showed a significant association of migraine with visual aura and incident atrial fibrillation (hazard ratio 1.30, 95% confidence interval 1.03–1.62, p = 0.02), but not for migraine without aura, compared to non-headache persons after multivariable adjustment for vascular risk factors. Twenty-two were included and analysed for this review. Articles without original data, such as guidelines, narrative reviews, editorials and others, were excluded. The first part of this review presents the neurobiology of SD, including overlaps between migraine aura and stroke models. According to the Migraine Research Foundation, around 39 million children and adults in the United States are affected. PubMed was searched for ‘migraine’ AND ‘atrial fibrillation’ and selected original investigations on the association of migraine and atrial fibrillation for our analysis. Researchers suggest that migraine with aura could increase the risk of stroke. The aim was to systematically review the current literature on the association between migraine and atrial fibrillation, which is a relevant risk factor for stroke. Your doctor might diagnose the migraine with aura based on your signs and symptoms, your medical and family history, and a physical exam. People who have migraine with aura are at a mildly increased risk of stroke. If you notice one or more of these signs in another person or in yourself, do not wait to seek help. Migraines are also more common in women than in men. Most ischemic strokes occur suddenly, and time is vital. However, the migraine aura can resemble more serious conditions, such as a stroke. But this isn’t necessarily cause for alarm. For a stroke to be classified as a migrainous stroke, the episode must occur along with a migraine with aura. Patients with migraine are at increased risk of stroke. The aura is often described as seeing flashing lights, a sensation of pins and needles, and/or feeling dizzy or unsteady Studies suggest migraine with aura doubles the risk of the most common type of stroke, involving a clot in an artery supplying the brain. For example, the association between migraine and ischemic stroke is reported to be stronger for strokes occurring among younger (ie, <50 years) than older individuals and for women than men.